How Emerging Technology Effects Modern Society Essays - Diploma

How Emerging Technology Effects Modern Society How Emerging Technology Effects Society: The microeconomics picture of the U.S has changed immensely since 1973, and the trends are proving to be consistently downward for he nation's high school graduates and high school dropouts. Of all the reasons given for the wage squeeze - international competition, technology, deregulation, the decline of unions and defense cuts technology is probably the most critical. It has favored the educated and the skilled, says M. B. Zuckerman, editor-in-chief of U.S. News and World Report (7/31/95). Since 1973, wages adjusted for inflation have declined by about a quarter for high school dropouts, by a sixth for high school graduates and by about 7% for those with some college education. Only the wages of college graduates are up. Of the fastest growing technical jobs, software engineering tops the list. Carnegie Mellon University reports, recruitment of its software engineering students is up this year by over 20%. All engineering jobs are paying well; proving that highly skilled labor is what employers are interested for potential employees. There is clear evidence that the supply of workers in the unskilled labor categories already exceeds the demand for their services, says L. Mishel, Research Director of Welfare Reform Network. In view of these facts, I wonder if these trends are good or bad for society. The danger of the information age is that while in the short run it may be cheaper to replace workers with technology, in the long run it is potentially self-destructive because there will not be enough purchasing power to grow the economy, M. B. Zuckerman. My feeling is that the trend from unskilled labor too highly technical, skilled labor is a good one! But, political action must be taken to ensure that this societal evolution is beneficial to all of us. Back in 1970, a high school diploma could still be a ticket to the middle income bracket, a nice car in the driveway and a house in the suburbs. Today all it gets is a clinker parked on the street, and a dingy apartment in a low rent building, says Time Magazine (Jan 30, 1995 issue). However, in 1970, our government provided our children with a free education, allowing the vast majority of our population to earn a high school diploma. This means that anyone, regardless of family income, could be educated to a level that would allow them a comfortable place in the middle class. Even restrictions upon child labor hours kept children in school, since they are not allowed to work full time while under the age of 18. This government policy was conducive to our economic markets, and allowed our country to prosper from 1950 through 1970. Now, our own prosperity has moved us into a highly technical world, that requires highly skilled labor. The natural answer to this problem, is that the U.S. Government's education policy must keep pace with the demands of the highly technical job market. If a middle class income of 1970 required a high school diploma, and the middle class income of 1990 requires a college diploma, then it should be as easy for the children of the 90's to get a college diploma, as it was for the children of the 70's to get a high school diploma. This brings me to the issue of our country's political process, in a technologically advanced world. Voting & Poisoned Political Process in The U.S. The advance of mass communication is natural in a technologically advanced society. In our country's short history, we have seen the development of the printing press, the radio, the television, and now the Internet; all of these, able to reach millions of people. Equally natural, is the poisoning and corruption of these media's, to benefit a few. From the 1950's until today, television has been the preferred media. Because it captures the minds of most Americans, it is the preferred method of persuasion by political figures, multinational corporate advertising, and the upper 2% of the elite, who have an interest in controlling public opinion. Newspapers and radio experienced this same history, but are now somewhat obsolete in the science of changing public opinion. Though I do not suspect television to become completely obsolete within the

Free Essays on Thoreau

In Henry David Thoreau’s Civil Disobedience, Thoreau takes a strong look at the government and the reasons why some government laws should not be followed. In Thoreau’s opening lines he states, â€Å"That government is best which governs not at all;† (4-5). At the time when this essay was written, slavery was not only legal but it was a law that blacks must be owned. Slaves had no rights. They were in America for the sole purpose of working for the white man. Thoreau states, â€Å"if one HONEST man, in this state of Massachusetts, ceasing to hold slaves, were actually to withdraw from this copartnership, and he locked up in the county jail therefor, it would be the abolition of slavery in America,†(341-345). Thoreau is simply asking for people to disobey the laws of slavery in order to free the slaves who are people, who are human, and who should be given the same rights as other human beings. In my opinion, it is this statement that Martin Luther King Jr. took to heart as he fought for equality for all people. Thoreau goes on to speak of a time when he was asked by the State to pay money to the clergy because his father attended church. Thoreau refused to pay, however another person instead paid the money for him. Thoreau stated, â€Å"I did not see why the schoolmaster should be taxed to support the priest, and not the priest the schoolmaster, but I supported myself by voluntary subscription. I did not see why the lyceum should not present its tax bill, and have the State to back its demand, as well as the Church,† (465-470). After that incident, Thoreau made a statement in writing and gave it to the clerk to let the State know that he did not want to be a member of any organization that he had not joined of his own accord. Lastly, Thoreau speaks of a poll tax. Thoreau seemed to question the use of such money and of course he refused to pay the tax. This time his refusal landed him in jail. It is believed that it is this one night in... Free Essays on Thoreau Free Essays on Thoreau Henry David Thoreau begins his poem â€Å"Woof of the Sun, Etheral Gauze† with a description of fog covering the sun. Woof of the sun, ethereal gauze, Woven of Nature's richest stuffs, Visible heat, air-water, and dry sea, Last conquest of the eye†¦// (ll. 1-4) At first glance, the preceding passage offers an ordinary image of the sun hidden behind clouds. Through oxymorons he presents the boundless qualities of the low cloud of fog; the phrases â€Å"visible heat,† air water,† and dry sea† each present a state beyond the physical world free from temporal restrictions. More importantly Thoreau depicts the clouds as â€Å"ethereal gauze,† illustrating the sheerness of the clouds, yet how too the clouds partially conceal the sun from the eye. This special treatment of diaphanous media- fog and smoke- is a unique feature in Thoreau’s poems â€Å"Mist,† â€Å"Fog,† â€Å"The Sluggish Smoke† and â€Å"Light-Winged Icarian Bird.† Thoreau employs these metaphors to represent the semi-obscured realm that connects the physical world from the spiritual realm. For Thoreau, there was no distinction between the physical world and the spiritual world unlike Ralph Waldo Emerson who believes ther e is a division. Images of fog are featured in Thoreau’s poetry to present the bridge between Nature and heaven. The images of smoke serve as a metaphor of the human imagination attempting to reach to connect the two realms. In the poem â€Å"Mist,† one can see Thoreau recognizing and retaining the beauty of the physical world, but also featuring metaphysical attributes to the fog imagery: Low-anchored cloud Newfoundland air, Fountain-head and source of rivers, Dew-cloth, dream drapery, And napkin spread by fays; Drifting meadow of the air, Where bloom the daisied banks and violets, And in whose fenny labyrinth The bittern booms and heron wades; Spirit of lakes and seas and rivers, Bear only perfumes and the scent O... Free Essays on Thoreau As a follower of transcendentalism, Thoreau projected individualism in his literary works, Walden and â€Å"Civil Disobedience.† Thoreau had a deep emphasis on nature, as displayed in his works, as well as his freedom and following conscience. Walden Pond was one of Thoreau’s favorite spots in Concord, Massachusetts. Walden Pond is a symbol for self-exploration; it must answer human nature depth for depth. Even as a very young child, he could stand alone among the trees at Walden Pond and not feel lonely. The people around his small town referred to Thoreau as â€Å"nature’s own child† (Reef 21). Thoreau spent more time outdoors than in the small cabin he built by Walden Pond. Thoreau took long walks in the woods and fields around his town in Concord, Massachusetts. While he was at Walden, Thoreau was alone quite often, but he was rarely lonely. Walden is a book about Thoreau’s experiences while living in the woods beside Walden Pond. Walden is not a long book, but it is filled with wonderful sentences that grab at your mind and stay in your ear (Burleigh 20). This book has helped many people think about and change their lives. Thoreau summed up his reasoning for living by Walden Pond by saying, â€Å"I went to the woods because I wished to live deliberately, to front only the essentials facts of life, and see if I could not learn what it had to teach, and not, when I came to die, discover that I had not lived† (Daugherty 15). Thoreau felt peaceful and at one with nature. He felt deeply about nature; he felt it reached right into your feelings. Yet thoughts (Ring 5). Thoreau felt that â€Å"Natural objects and phenomena are the original symbols or types which express our thoughts and feelings, and yet American scholars, having little or no root in the soil, commonly strive with all their might to confide themselves to the imported symbols alone. All the true growth and experience, the living speech, they would fa... Free Essays on Thoreau In Henry David Thoreau’s Civil Disobedience, Thoreau takes a strong look at the government and the reasons why some government laws should not be followed. In Thoreau’s opening lines he states, â€Å"That government is best which governs not at all;† (4-5). At the time when this essay was written, slavery was not only legal but it was a law that blacks must be owned. Slaves had no rights. They were in America for the sole purpose of working for the white man. Thoreau states, â€Å"if one HONEST man, in this state of Massachusetts, ceasing to hold slaves, were actually to withdraw from this copartnership, and he locked up in the county jail therefor, it would be the abolition of slavery in America,†(341-345). Thoreau is simply asking for people to disobey the laws of slavery in order to free the slaves who are people, who are human, and who should be given the same rights as other human beings. In my opinion, it is this statement that Martin Luther King Jr. took to heart as he fought for equality for all people. Thoreau goes on to speak of a time when he was asked by the State to pay money to the clergy because his father attended church. Thoreau refused to pay, however another person instead paid the money for him. Thoreau stated, â€Å"I did not see why the schoolmaster should be taxed to support the priest, and not the priest the schoolmaster, but I supported myself by voluntary subscription. I did not see why the lyceum should not present its tax bill, and have the State to back its demand, as well as the Church,† (465-470). After that incident, Thoreau made a statement in writing and gave it to the clerk to let the State know that he did not want to be a member of any organization that he had not joined of his own accord. Lastly, Thoreau speaks of a poll tax. Thoreau seemed to question the use of such money and of course he refused to pay the tax. This time his refusal landed him in jail. It is believed that it is this one night in...

What does the term Model Minority refer to According to Chan, how Essay

What does the term Model Minority refer to According to Chan, how accurate is this perspective Explain their argument. Who is excluded from this perspective Is it harmful - Essay Example The publicity that has been given to the Asian minorities and brought forth the term â€Å"model minority† is due to factors like low crime rates among young people in these communities and their higher socio economic status as compared to other minorities. Media publicity that propagated this view described how Asian Americans had been able to achieve a higher social class and standing through cultural mechanisms like hard work, their frugal lifestyles, their sacrifices for children and their family ties (Pyong 2006:80). The criticism levelled against the model minority program contends that the publicity hype does not take into account all the relevant factors. For instance, the claims about Asian Americans achieving a higher economic status than white Americans in some cases, does not take into account the fact that in most Asian American families, more than one person in the family was earning and contributing, which helped to account for the higher family income. (Chan 168). Furthermore, while it was true that Asian Americans such as Chinese and Japanese had significantly higher levels of schools than non-Hispanic whites, their median incomes in the long run were no higher because the returns that should have come to them due to their higher levels of schooling were lower than the whites. According to the Human capital theory, the skills and knowledge gained by a worker through education and experience comprises human capital, hence the greater the capital, the greater should be the wages. Where Asian Americans are concerned however, this does not appear to hold good, since they receive lower wages in general despite higher education. The model minority thesis has also been criticized on the grounds that it does not take into consideration the fact that most Asian Americans live in cities where wages in general are higher, as are also expenses. Comparing

Employee Perceptions of Equity in Performance Appraisals Essay

Employee Perceptions of Equity in Performance Appraisals - Essay Example This proposed study is of considerable interest as performance appraisals rest solely on the judgment of the appraising manager and the process generally lacks a "bias  This proposed study is of considerable interest as performance appraisals rest solely on the judgment of the appraising manager and the process generally lacks a "bias   Research Proposal 3control" methodology. These judgments inherent in appraisal often decide compensation and career progression and the employee has little or no opportunity to influence the outcome of this process (Davis & Landa, 1999).  Bias, not necessarily negative, can also be attributed to relationships between the appraising manager and other employees, in which the rater may inflate the performance rating of another employee based on closeness and camaraderie. This creates a situation where performance appraisals are perceived as unfair, damaging manager/employee relationships.  Because of these factors, this study will identify the di fferent types of appraisal bias, where these biases stem from, and how long-term, working relationships between manager and subordinate can be strengthened through possible bias control methods. In order to assess these factors, the following questions will be analyzed through primary research within the study:1. To identify employee perceptions of the performance appraisal process –  Ã‚  What sources of perceived bias exist in contemporary business organizations?

Business contiunity Management is a luxury in times of recession Essay

Business contiunity Management is a luxury in times of recession - Essay Example Matthys (2009) lists some disruptive or unexpected events which may occur to an organization that may bring harm and other major impacts to the organization and community. Example of events are broken equipments; computer viruses and other IT fraud; phone, internet, power and gas failure; natural calamities; terrorist attacks and all forms of pandemics; and other events that hinder the flow of operations of the business. 2. RECESSION VS. BUSINESS CONTINUITY MANAGEMENT When recession strikes, it is the period when the Gross Domestic Product (GDP) growth is negative. GDP is the total value of the annual output of goods and services produced within a nation's borders. It excludes the foreign output of domestic firms and includes the domestic output of foreign firms (Mankiw, 2008). Because of low GDP, companies' level of output they produce annually has been reduced. One common mistake of some companies during recession is when there is less money to go around, they will cut off their bu dgets. When this happens, it is inevitable to lay off key employees to reduce their expenses. When there's a decrease of employment rate in the economy, people will be earning lower incomes that will result to a decrease of consumer spending. Businesses then will be forced to lower the prices of their goods that will eventually cause a deflation (KCLAU, n.d.). The 9/11 World Trade Center (WTC) terrorist attack is an example in which local and national economies were pushed into recession. The Fiscal Policy Institute (2001) categorized the three types of direct effects of the WTC fall. First were the businesses that comprise the WTC area. Most of them are securities, insurance carrier, real estate operations and data processing services. Thousands of people working at the hotels, restaurants, banks and other establishments near the WTC lost their jobs, hence Lower Manhattan experienced decline of sales. Furthermore, other industries in New York were also greatly affected in the attac k. Example is the air transport industry which comprises 54,000 jobs was shut down for few days not just because of the attack but also most people were already scared to travel by air. This resulted to the decline of tourism. Lastly, the household spending in New York was reportedly made a huge impact during the attack and its aftermath. New York's annual consumption spending is over $200 billion. A 10% one month reduction in consumer spending was assumed by FPI resulting to 9600 job loss. Before the 9/11 attack, it was stated in the Info Security News Magazine of 2000 that 90% of losses will be reduced if an organisation had established beforehand an effective BCP in case of any unwanted event. After the attack, a study conducted that about 81% of CEOs had said that their company plans wouldn't be able to survive with that kind of incident (Naef, 2003). 3. OBJECTIVE CATEGORIES 3.1 STRATEGIC To fully understand the whole coverage of Business Continuity Management, an organization m ust begin first in the development of the business continuity strategies. These are courses of actions used in the development and implementation of business continuity plan which are approved, documented and funded by the management of the organization. The results of the

Apoptosis And Inhibitor of apoptosis proteins Family: A

Apoptosis And Inhibitor of apoptosis proteins Family: A   Background Apoptosis is an orchestrated biological cellular process that occurs in physiological and pathological conditions(1). It is essential for regulating development, homeostasis, and immune-system function in organisms(2). In mammalian cells, apoptosis is mediated by a family of cysteine proteases named caspases which are initially expressed in cells as inactive procaspase precursors and are activated by two pathways, the extrinsic ( or death receptor) and intrinsic (or mitochondrial) apoptotic pathways(1). The extrinsic pathway is activated by the binding of ligands such as Fas ligand (FasL) and tumour necrosis factor (TNF) to death receptors on the cell surface, FAS and the TNF receptor (TNFR), respectively, which leads to the formation of the death-induced signalling complex (DISC)(3)(4). DISC recruits caspase-8 and promotes the cascade of procaspase activation that follows(5). The intrinsic pathway is triggered by extracellular and intracellular stresses, such as high cytosolic [ca+2 ], hypoxia, severe oxidative stress, DNA damage(5), which results in the permeabilization of the outer mitochondrial membrane, the release of pro-apoptotic molecules such as cytochrome C and others into the cytoplasm(6), the formation of the apoptosome- a large protein complex that is made up of cytochrome C, apoptotic protease activating factor 1 (APAF1) and caspase-9 and caspase activation(7). On the other hand, cell death is also modified by other mitochondrial proteins such as apoptosis-inducing factor(AIF), second mitochondria- derived activator of caspase (Smac), direct IAP Binding protein with low PI (DIABLO)   and Omi/high temperature requirement protein A (Htr A2)(7). Smac/ DIABLO or Omi/HtrA2 induces cell death independently of caspase activation by counteracting inhibitor of apoptosis (IAP)- mediated caspase inhibition(7)(8)( Fig. 1). The upstream caspase for the intrinsic pathway is caspase 9, while that of the extrinsic pathway is caspase 8. The intrinsic and extrinsic pathways cleave the precursor forms of effector caspases, such ascaspase-3, caspase-6 and caspase-7(9). Activated effector caspases cleave many vital cellular proteins such as protein kinases, cytoskeletal proteins, DNA repair proteins and inhibitory subunits of endonucleases family and break up the nuclear scaffold and cytoskeleton(9). They also activate DNAase, that further degrade nuclear DNA(10), which together contribute to the typical morphological changes in apoptosis. Dysregulation of apoptosis has been implicated in numerous pathological conditions, including cancer(1). Besides, targeting the apoptotic pathways for cancer treatment is supported by several findings emphasizing the role of aberrant apoptosis in tumorigenesis and also resistance to anticancer treatment. Evasion from apoptosis is critical for tumor growth and a hallmark of cancer(11). One of the mechanisms by which evasion of apoptosis occurs is   disrupted balance of pro-apoptotic and anti-apoptotic proteins(1). A delicate balance between pro-apoptotic and anti-apoptotic mechanisms determines whether a cell death signal can activate the apoptotic program. It is not the absolute quantity but rather the ratio of these pro-and anti-apoptotic proteins that controls the regulation of cell death. In this balance, pro-apoptotic proteins activate apoptosis and anti-apoptotic proteins inhibit apoptosis(12)(13). Inhibitors of apoptosis protein (IAPs)   are important members of the anti-ap optotic family of proteins that can inhibit   caspase activation and play a key role in regulating of apoptosis in many species(1). Inhibitor of apoptosis proteins (IAPs): The inhibitor of apoptosis proteins are a group of structurally and functionally similar proteins that regulate programmed cell death, cytokinesis and signal transduction(14). The   IAP gene is 1.6 kb in size encoding a 31 kDa protein with a zinc finger-like motif. Many IAP family members have been identified in almost all species from viruses to mammals(15). They are characterized by the baculovirus IAP repeats (BIR) domain at the N- terminus, the name of which derives from the original discovery of these apoptosis suppressors in the genome of baculoviruses(16). The BIR domain contains approximately 70 amino acids. Although the number of BIR domains varies among IAP members, each BIR domain is made up of cysteine and histidine residues in a well-defined pattern (CX2CX16HX6C)(15). IAP acts as endogenous inhibitor of caspases by binding of their conserved BIR domains to the active sites of caspases in vitro and   vivo. IAPs inhibit caspases by promoting the degradation of active caspases, or by sequestering the caspases away from their substrates(17). When IAP family members are overexpressed, cancer cells no longer proceed to apoptosis and become increasingly resistant to standard chemo- and radiation therapies(18)(19). Many studies have established a circumstantial association between IAPs and cancer. Pathological overexpression of several IAP family members has been detected in several classes of human cancers(20)(21)(22). The eight IAPs identified in humans are cIAP1, cIAP2, NAIP, Survivin, XIAP, apollon, ILP-2 and livin(23). Interestingly, many data have shown that c-IAP1, c-IAP2 and XIAP are   broadly expressed in normal cells(24)(22). In normal tissues, IAPs could have some potential physiological roles, such as the regulation of the immune system(25), the response to cell damage(25), cell survival and differentiation(26). On the other hand, it has been proven in many studies that survivin, unlike other IAPs, is prominently expressed in vast majority of neoplasms but not in differentiated normal tissues(27). Survivin has been reported to be overexpressed in various cancers including breast and lung cancer, prostate, gastric, colon, bladder and esophageal carcinomas, osteosarcomas and lymphomas(28)(29). Overexpression of survivin was also found to be significantly associated with poor prognosis and decreased survivial rates in many cancers(30)(31). Survivin: Survivin (also Called IAP 4) is a protein with a crucial role in regulating both cell division and apoptosis. It is the smallest member of the IAP family(29). Survivin, a 16.5 kDa intracellular   protein of 142 amino acid, was discovered in 1997 by Ambrosini and colleagues(32). Structurally, survivin contains a single BIR domain. This domain is essential for its anti-apoptotic activity(33). However, instead of a ring finger domain (RING) near the C-terminus shared by others members of the IAPs, survivin contains a C-terminus alpha-helical coiled-coil (CC) domain which is thought to be important for its interaction with microtubules, hence its roles in cell cycle(34)(35) In normal tissues, survivin shows cell -cycle dependent expression during cell division. Its expression increases in G2/M phase and decreases rapidly in G1(29). The regulation of survivn expression and function is complex and can occur at various levels, including transcriptional regulation, post-translational modification, and protein stability regulation(27). it is regulated by a number of factors such as: NF-nB(36), insulin-like growth factor I/mTOR(37), Ras oncogene family(38), E2F, Sp1, TCF, and heat shock protein (Hsp) 90(39)(40).   Survivin is also regulated by p53 wild type. Additionally, post-transcriptional phosphorylation has been proven to play a   regulatory role in survivin activation(41). Biologic function of survivin Survivin as an inhibitor of apoptosis The mechanism by which survivin inhibits apoptosis is still controversial. Initially, survivin and other IAPs were postulated to inhibit apoptosis directly by interfering with the function of caspase-3, caspase- 7, and caspase-9(42).   In support of this model, it was shown that survivin can interact with Smac/DIABLO physically, thus placing survivin in a central position in the dynamic balance of proapoptotic and antiapoptotic factors(43). However, Structural analyses of survivin indicated later that any effect on caspase should be indirect, as it lacks the amino acid sequence that is essential in other IAPs for caspase binding. Also, the survivin gene is highly conserved in a wide range of organisms, and all of its orthologues are involved in mitotic regulation but not in cytoprotection(44).   Studies of cells from survivin-knockout mice have cast further doubt on the existence of a direct link between survivin and apoptosis(45). Later experiments indicated that Survivin inhibits active caspase-9 but not active caspase-3 and caspase-7. And, survivin mediated inhibition of caspase-9 requires interaction and cooperation with other molecules such as   HBXIP (hepatitis B X-interacting protein)(46) and   XIAP (X-linked inhibitor of apoptosis protein) which also known as inhibitor of apoptosis protein 3 (IAP3)(47) (Fig. 3). Survivin also provides cytoprotection to cells through the inhibition of the AIF pathway, which is known to induce caspase-independent DNA fragmentation(48). Survivin as a promotor of mitosis The cell- cycle dependent expression of survivin in normal tissues   supports strongly its role in cell division. During mitosis, survivin acts in a narrow time window at metaphase and anaphase. It is acting as an interphase between the centromere/central spindle and the chromosomal passenger complex (CPC)(49). CPC is a hetero-tetrameric complex which localizes to different sites at different times during mitosis, and   is composed of four components:   Aurora-B Kinase (enzymatic component), Borealin/Dasra, Survivin and inner centromere protein (INCENP)(50)(51). CPC is essential for proper chromosome segregation and cytokinesis(52). Inactivation of mammalian survivin -or its orthologues in lower organisms results in cytokinesis abnormalities, particularly spindle defects(53)(54) (Fig. 3)(55). Survivin facilitating angiogenesis In addition to its roles in apoptosis and mitosis, survivin   promotes angiogenesis. it is strongly expressed in endothelial cells (EC) during   the proliferative phase of angiogenesis(56)(57) and the antisense-mediated suppression of survivin   during angiogenesis stimulates vascular regression in vitro(58). Besides, exposure of cultured vascular EC to angiogenic factors such as VEGF and bFGF result in increasing survivin expression (both mRNA and protein)(59)(60). Survivin expression In normal physiological conditions, survivin is usually expressed in   embryonic lung and fetal organs in the developmental Stages(61). The protein is also detected in mature tissues with high proliferation potential such as thymus, placenta, CD34+ stem cells and basal colonic epithelial cells(61)(62)(63). However survivin seems to be selectively expressed in transformed cells and in most human cancers. Many studies have shown that survivin, unlike other IAPs, is prominently expressed in the vast majority of neoplasms but not in the differentiated normal tissue(27). Based on detection of protein by immunohistochemistry and mRNA by polymerase chain reaction techniques, overexpression of survivin has been reported in various human malignancies including lung cancer(64), breast cancer(65)(66); stomach(67)(68), esophagus(69), liver(70)(71), ovary cancers(72), brain(73) and hematological cancers(74). Additionally, the immunological responses which detected against survivin supports its specific up-regulation in malignant cells(75)(76). Survivin protein has also been shown to induce cytotoxic T-lymphocytes (CTL) response in   breast cancer, melanoma and chronic lymphatic leukemia patients(76). Survivin expression can be deregulated in cancer by several mechanisms, including amplification of the survivin locus on chromosome 17q25 (77), demethylation of survivin exons(78), increased promoter activity(79), and increased upstream signaling in the phosphatidylinositol 3-kinase or mitogen activated protein kinase pathways(80). Overall, increased survivin expression in several malignancies is associated with cancer survival or disease recurrence, and resistance to chemotherapy or radiotherapy. In a study of 275 patients with breast cancer demonstrated that survivin was a significant prognostic factor and predicted the outcome independent of patients age, tumor size and histologic grade(81). In the case of ovarian cancers, survivin expression was correlated with poor prognostic factors such as: high histologic  grade, mutant p53, and poor histologic type(81)(82). Also, previous studies demonstrated that survivin was expressed in benign brain and pituitary tumors. Although survivin   was also present in normal pituitary tissue,   the level of the gene expression was 6-fold higher in tumors than in normal pituitary tissue(83). In a study of 222   patients who underwent radical cystectomy, survivin was expressed in 64% of bladder tumors and 94% of malignant lymph nodes, but not in normal bladder specime ns and its expression correlated with disease recurrence and disease-specific mortality(84).   Also, increased survivin expression has been associated with an unfavorable survival or disease recurrence in colorectal cancer(85), particularly in stage II disease in esophageal cancer(86), hepatocellular carcinoma(87), lung cancer(88), glioma(89), leukemia(90), and other cancer types. A   study in oral cancer demonstrated that the extent of survivin expression was negatively correlated with the degree of differentiation(91). Additionally, survivin overexpression may be a predictive factor to determine response to chemotherapy and radiotherapy in patients with bladder cancer(92), breast cancer(93), multiple myeloma(94), lung cancer(95) and lymphoma(96)(97). On other hand, patients with lower survivin expression were more responsive to preoperative chemotherapy with 5-flourouracil and cisplatin in esophageal cancer(98). It is also reported that patients with lower survivin expression in pretreatment biopsies were more responsive to radiotherapies in rectal cancer(99). While Overexpression of survivin was associated with   resistance to a taxol-based   therapy for ovarian carcinomas(100). In addition to full-length transcript (survivin (wild type)), five splice variants, which result from splicing of survivin BIRC5 gene pre-messenger RNA (mRNA), have been described: survivin-ΔEx3, survivin-3B, survivin-2ß, survivin2ÃŽ ± and survivin 3ÃŽ ± with different structure and function(101)(102)(103). Previous studies showed that an imbalance in the alternative transcript ratios may affect the cell to be resistant or sensitive to apoptosis(104). This alternative splicing of Survivin has been shown to have correlation with disease activity in various patient studies. For example, studies showed that Survivin-ΔEx3 and survivin-3B were found to be highest in tumors with advanced histological grade and were associated with poor prognosis(105)(106). On other hand, the expression of survivin-2ß was significantly higher in small tumor size and was inversely associated with axillary node positive carcinomas(106). Besides different splicing forms, immunohistochemical studies have demonstrated that survivin also localized   in distinct nuclear and cytoplasmic subcellular pools. Cytosolic Survivin is believed to act as apoptotic suppressor while nuclear Survivin is postulated to regulate cell division(29). There are conflicting data of pathological significance of nuclear Survivin.   Some Splicing studies showed that nuclear staining of survivin is associated with favorable prognosis(107), while others showed Its expression in the nuclei of tumor cells appears to be associated with unfavorable clinical outcomes(108)(109). Also, the cellular localization of Survivin isoforms   differs. while survivin-2ß   and Survivin 2a are localized in both nuclear and cytoplasmic compartments, survivin-ΔEx3 is localized in both mitochondria and nucleus(110). Additionally, Methylation and Phosphorylation are critical requirements for survivin function. Several observations show that survivin is unmethylated in cancer but may be selectively methylate  d in normal tissues with individual variations(111)(112). Methylation may play an important role in the p53 mediated suppression of survivin(113). Another critical requirement for survivin function is the phosphorylation on Thr34(114) Treatment approaches: Due to important role of Survivin in tumor cell division, apoptosis, chemo resistance and survival, survivin represents a unique target for biologic therapy in many human malignancies. Several novel experimental therapeutic strategies have been developed to block the expression or function of Survivin in tumour cells. These include immunotherapeutic approaches to induce immune response against Survivin, small molecule inhibitors/antagonists of   survivin function, and nucleic acid based approaches which interfere with Survivin gene expression(115)   such as antisense oligonucleotides (ASOs), ribozymes and small interfering RNAs (siRNAs)(116). Also, Vaccine approaches such as dendritic cell based (DC) vaccines, DNA vaccines(117), peptide vaccines for Survivin have also been evaluated in preclinical or clinical studies. Survivin ASOs were first used against malignant melanoma cell lines. Transfection with the ASOs triggered spontaneous apoptosis linked to decreased endogenous survivin expression(118) . Treatment with LY2181308, a specific inhibitor of Survivin mRNA which has already entered the phase 1 trial(119). YM-155 is a novel small-molecule survivin suppressant which inhibits survivin mRNA transcription and protein expression in p53-deficient cancer cells in vitro(120). YM155 has also shown to be effective in vivo models of prostate, pancreatic, and lung cancer(120)(121). Ribozyme mediated approaches have also been evaluated for inhibition of Survivin expression. Down-regulation of human Survivin gene expression and increased apoptosis was achieved by using two hammerhead ribozymes (RZ-1, RZ-2) targeting human Survivin mRNA (122) PIQL: Success-Tolerant Query Processing in the Cloud PIQL: Success-Tolerant Query Processing in the Cloud Advanced Topics in Foundations of Databases PIQL: Success-Tolerant Query Processing in the Cloud Stavros Anastasios Iakovou Introduction In our days it is widely know that modern web applications are directly linked with databases. In addition, the number of the users is highly increas- ing through the time and as result the related databases start overloading. Furthermore, despite the fact that data indepence would be ideal for im- plemeting lithe applications developers abandoned this idea in order to avoid expensive queries. Hence, Michael Armbrust et al.[1] implemented a new declarative language called PIQL, a scale independent language. A large number of frameworks have already appeared in order to assist developers to create modern web applications. However, this plethora of websites with millions of users led to database failures due to lack of request managing. As a result, there was a demand on implementation of a new system that will control all these requests and provide efficient results to users. A few methods have introduced and one of the most popular is NoSQL. Despite the fact that NoSQL provided a high level interface, data indepen- dence created scalability problems since a large number of queries took a lot of time. This led to to several issues like performance failing and user disatisfaction as well. In order to avoid this bad situation scientists hand coded key/value implementations. On the one hand, this provided the de- sirable scalability but, on the other hand is was not easy enough for the developers to write that kind of code to parallelize their queries so as to fi achieve high scalability. Another significant issue is time consuming functions rewrites. Now, once we talked about several problems occured by queries in the next section we will discuss about PIQL. More specifically, we will present this method and give a brief summary of the implementation. In the rest of the document we will discuss about the performance of the previous imple- mentation. What is PIQL? In this section we will discuss and analyze the PIQL (PerformanceInsightful Query Language) model. One important advantage of PIQL is that intro- duced the notion of scale independency. More specifically, the model pre- serves the logical data independence. The most significant about data this technique is that performace maintains not only on small datasets but also in large as well. For this reason this is called success-tolerant since the success is for every large dataset. But why PIQL is successful? The answer is on the limitation on key/value store operations. As we previously mentioned, one goal of PIQL is to avoid issues when the database gets larger. PIQL uses static analysis in order to fi the correct number of operation in every step of the execution. Before we move to the next step of the analysis of the methodology we should mention the four queries classes. The fi one is called constant since the processing time is constant. The second one is the bounded class. More specifically this class refers to bounded data when the site becomes more popular. For instance, in case of Facebook every user has a limit of 5000 friends. The third class is called sub-linear or linear and is referring to queries that become more successfull when the data increase linearly. The last one is Super-linear where intermediate calculations are necessary for the queries. Now, once we mentioned all the necessary theoritical parts of PIQL we will discuss on its structure. Every server is directly connected with a Distributed Key/Value Store. Hence, this methodology maintains the scalability and the response time is now predictable. A significant drawback of this technique is that a specific key/value store is required so as to maintain data locality. On the other hand, this method is non-blocking and according to Chen et al.[2] can reduce memory latency. Another important benefit of PIQL is that extends the cardinality con- straint of regular direction to diff ent directions as well. More specifi , these cardinalities provide several information on its relationships. For in- stance, a Facebook user should have no more than 5000 friends. This is a very significant information since selecting the wrong number for limita- tions can lead back to the previous problems. Thinking again the Facebook limitations for the maximum number of friends on Facebook, according to Brandtzg et al.[3] a significant issue that occurs is the lack of privacy. Hence, the limitations are not only important for the performance but also for the user protection as well. In addition, the same person can create a new profit for free and add his new friends there. As a result, 5000 friends is not actually a limitation for a user and is provided in terms of privacy and performance. According to Michael Armbrust et al.[1] their algorithm for scale inde- pendent optim ization contains two phases. The fi one is reffering to stop operator insertion. In order to maintain scalability, the algorithm starts by fi a linear join ordering on the query parser. Depsite the fact that stop operator is already contained due to LIMIT which in contained in the reg- ular query, scientists have introduced data-stop operators which are pushed in lower levels in order to preserve the initial rules without the demand of  restart the whole system. Next, after fiphase 1 the second step which is called remote op- erator matching. As we previously mentioned we should ensure scalabiliy. Hence, the intermediate results are bounded. But how all these logical op- erators are mapped on remote operators? For Index Scan, that means that maximum one attribute can be affected by predicates. As for Index Foreign Key join the number of tuples after the join is less than or than the tuples of the initial plan. References [1] Armbrust, Michael, et al. PIQL: Success-tolerant query processing in the cloud. Proceedings of the VLDB Endowment 5.3 (2011): 181-192. [2] Chen, Tien-Fu, and Jean-Loup Baer. Reducing memory latency via non- blocking and prefetching caches. Vol. 27. No. 9. ACM, 1992. [3] Brandtzg, Petter Bae, Marika Lders, and Jan Hvard Skjetne. Too many Facebook friends? Content sharing and sociability versus the need for pri- vacy in social network sites. Intl. Journal of HumanComputer Interaction 26.11-12 (2010): 1006-1030.

i hate fish sticks :: essays research papers

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